| 產(chǎn)品編號(hào) | bsm-35030M |
| 英文名稱 | human CD62p Mouse mAb |
| 中文名稱 | P選擇素/白細(xì)胞內(nèi)皮細(xì)胞粘附分子3單克隆抗體 |
| 別 名 | P-selectin; CD_antigen: CD62P; CD62 antigen-like family member P; GMP 140; GMP-140; GMRP; Granule membrane protein 140; Granulocyte membrane protein; GRMP; LECAM 3; LECAM3; Leukocyte endothelial cell adhesion molecule 3; Leukocyte-endothelial cell adhesio |
| 研究領(lǐng)域 | 心血管 細(xì)胞生物 免疫學(xué) 干細(xì)胞 細(xì)胞粘附分子 上皮細(xì)胞 |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號(hào) | 5B3 |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | Flow-Cyt=1:1000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 88 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD62p |
| 亞 型 | IgG1 |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008] Function: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. Subunit: Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. DISEASE: Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Similarity: Belongs to the selectin/LECAM family. Contains 1 C-type lectin domain. Contains 1 EGF-like domain. Contains 9 Sushi (CCP/SCR) domains. SWISS: P16109 Gene ID: 6403 Database links: Entrez Gene: 6403 Human Entrez Gene: 20344 Mouse Omim: 173610 Human SwissProt: P16109 Human SwissProt: Q01102 Mouse Unigene: 73800 Human P-選擇素(P—selectin)是細(xì)胞黏附分子選擇素家族的主要成員，又稱CD62p，可以介導(dǎo)各種白細(xì)胞和腫瘤細(xì)胞的粘附。 CD62p又稱GMP—140或PADGEM蛋白(血小板活化依賴α顆粒膜蛋白),它在血小板與單核細(xì)胞及中性粒細(xì)胞相互作用中起關(guān)鍵作用。 |
| 產(chǎn)品圖片 |
scatter diagram showing peripheral blood platelet stained with bsm-35030M. The cells were incubated with the antibody (bsm-35030M,1:1000) for 30 min at 22°C.The secondary antibody used for 40 min at room temperature .Acquisition of >20,000 events was performed.
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