| 產(chǎn)品編號 | bs-23866R |
| 英文名稱 | Neuropilin 1 Rabbit pAb |
| 中文名稱 | 神經(jīng)纖毛蛋白1抗體 |
| 別 名 | Neuropilin-1; NRP-1; Neuropilin1; Neuropilin 1; BDCA4; CD 304; CD304; DKFZp686A03134; DKFZp781F1414; NEL like protein 1; Nel related protein 1; Neuropilin1; Neuropilin 1; Neuropilin1 transmembrane receptor; NP1; NRP 1; NRP; NRP1; OTTHUMP00000020818; OTTHU |
| 研究領(lǐng)域 | 免疫學(xué) 神經(jīng)生物學(xué) 生長因子和激素 細(xì)胞膜受體 內(nèi)皮細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 100 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Neuropilin 1: 751-850/923 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011] Function: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. Subunit: Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Tissue Specificity: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Similarity: Belongs to the neuropilin family. Contains 2 CUB domains. Contains 2 F5/8 type C domains. Contains 1 MAM domain. SWISS: Q5T7F3 Gene ID: 8829 Database links: Entrez Gene: 8829 Human Entrez Gene: 18186 Mouse Omim: 602069 Human SwissProt: O14786 Human SwissProt: Q5T7F3 Human SwissProt: P97333 Mouse SwissProt: Q6PAR3 Mouse Unigene: 131704 Human Unigene: 653996 Human Unigene: 271745 Mouse Unigene: 10815 Rat CD304是一種神經(jīng)元受體，被認(rèn)為表達(dá)于眾多的非造血細(xì)胞上，包括神經(jīng)元、內(nèi)皮細(xì)胞和腫瘤細(xì)胞。在體外單核細(xì)胞和造血前體細(xì)胞衍生的CD1a+樹突狀細(xì)胞是CD304（BDCA-4/Neuropilin-1）。 與CD303(BDCA-2)一樣，CD304(BDCA-4)抗原特異性地表達(dá)于人血液和骨髓中的漿樣樹突狀細(xì)胞。與CD303(BDCA-2)不同的是，CD304(BDCA-4)在培養(yǎng)的漿樣樹突狀細(xì)胞上表達(dá)上調(diào)，同時在培養(yǎng)的髓系細(xì)胞能被誘導(dǎo)表達(dá)。在感染的扁桃體中，CD304(BDCA-4)不僅表達(dá)于漿樣樹突狀細(xì)胞，而且在其它細(xì)胞上也能檢測到，如初級濾泡B輔助性記憶T細(xì)胞。 |
| 產(chǎn)品圖片 |
Sample:
Fatal brain (Mouse) Lysate at 40 ug
Primary: Anti-Neuropilin 1? (bs-23866R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 100 kD
Observed band size: 130 kD
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