| 產(chǎn)品編號(hào) | bs-19213R |
| 英文名稱(chēng) | NEURL2 Rabbit pAb |
| 中文名稱(chēng) | E3泛素連接酶蛋白NEURL2抗體 |
| 別 名 | Neuralized E3 Ubiquitin Protein Ligase 2; C20orf163; Chromosome 20 Open Reading Frame 163; Neuralized Homolog 2(Drosophila); Neuralized-Like 2(Drosophila); Neuralized-Like Protein 2; Neuralized Homolog 2; OZZ-E3; OZZ; NEUL2_HUMAN; |
| 研究領(lǐng)域 | 細(xì)胞生物 激酶和磷酸酶 泛素 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 32 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NEURL2: 1-100/285 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013] Function: Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma By similarity. Subcellular Location: Cytoplasmic Tissue Specificity: Expressed specifically in skeletal and cardiac muscles. Similarity: Probable component the ECS(NEURL2) E3 ubiquitin-protein ligase complex consisting of TCEB2/Elongin B, TCEB1/Elongin C, CUL5, RBX1 and NEURL2. Interacts with CTNNB1 By similarity. SWISS: Q9BR09 Gene ID: 140825 Database links: Entrez Gene: 140825 Human Entrez Gene: 415115 Mouse Omim: 608597 Human SwissProt: Q9BR09 Human SwissProt: Q9D0S4 Mouse |
