| 產(chǎn)品編號 | bs-9879R |
| 英文名稱 | protein 4.2 Rabbit pAb |
| 中文名稱 | 紅細(xì)胞膜蛋白4.2抗體 |
| 別 名 | protein 4.2; protein4.2; EPB42; EPB42_HUMAN; Erythrocyte membrane protein band 4.2; Erythrocyte protein 4.2; Erythrocyte surface protein band 4.2; MGC116735; P4.2; PA; SPH5. |
| 研究領(lǐng)域 | 心血管 細(xì)胞表面分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 77 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EPB42/protein 4.2: 201-300/691 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
protein 4.2;
protein4.2;
EPB42;
EPB42_HUMAN;
Erythrocyte membrane protein band 4.2;
Erythrocyte protein 4.2;
Erythrocyte surface protein band 4.2;
MGC116735;
P4.2;
PA;
SPH5. Function: Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. Subunit: Oligomer. Interacts with the cytoplasmic domain of SLC4A1/band 3 anion transport protein. Subcellular Location: Cell membrane. Cytoplasm > cytoskeleton. Cytoplasmic surface of erythrocyte membranes. Post-translational modifications: Both cAMP-dependent kinase (CAPK) and another kinase present in the red-blood cells seem to be able to phosphorylate EPB42. DISEASE: Defects in EPB42 are the cause of spherocytosis type 5 (SPH5) [MIM:612690]; also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported. Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family. SWISS: P16452 Gene ID: 2038 Database links: Entrez Gene: 2038 Human Omim: 177070 Human SwissProt: P16452 Human Unigene: 368642 Human Involvement in disease:Defects in EPB42 are the cause of spherocytosis type 5 (SPH5); also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported. |
