| 產(chǎn)品編號 | bs-6757R |
| 英文名稱 | BCA2 Rabbit pAb |
| 中文名稱 | 乳腺癌相關(guān)基因2抗體 |
| 別 名 | BCA2; Breast cancer associated gene 2; CL469780; Rabring 7; RING finger protein 115; RNF115; Zinc finger protein 364; ZNF364; ZNF 364; RN115_HUMAN. |
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Specific References (1) | bs-6757R has been referenced in 1 publications.
[IF=5.033] Xiao-Ting Wu. et al. RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination. Cancer Metab. 2021 Dec;9(1):1-12 WB,IHC ; Human.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 細(xì)胞類型標(biāo)志物 腫瘤細(xì)胞生物標(biāo)志物 鋅指蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 34 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZNF364/BCA2/RNF115: 161-260/304 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The RING finger family of proteins possess ubiquitin ligase activity and play pivotal roles in protein degradation and receptor-mediated endocytosis. The autoubiquitination activity of ZNF364 indicates that it is a novel RING-type E3 ligase. Its effects on cell growth indicate that ZNF364 may be important for the ubiquitin modification of proteins crucial to breast carcinogenesis and growth. Function: Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking. Subunit: Interacts with RAB7A. Subcellular Location: Cytoplasm, cytosol (By similarity). Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes (By similarity). Tissue Specificity: Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells. Post-translational modifications: RING-type zinc finger-dependent and E2-dependent autoubiquitination. Similarity: Contains 1 RING-type zinc finger. SWISS: Q9Y4L5 Gene ID: 27246 Database links: Entrez Gene: 27246 Human Entrez Gene: 67845 Mouse SwissProt: Q9Y4L5 Human SwissProt: Q9D0C1 Mouse Unigene: 523550 Human Unigene: 386792 Mouse |
